I think what might be different this time is influencers. If Critical Role abandoned D&D completely, I think they’d probably stay popular and whatever system they switched to would get a lot of attention. I also think that they’d be likely to use a system that isn’t math heavy, and allows for a lot of role playing and acting.
The problem would probably be splintering. But, if a tiny company like Paizo made such a big impact on the D&D ecosystem with virtually no ad money back in the 3.5 days, just imagine what could happen today when so many D&D influencers exist. If they worked together on something, it could be a major change to the D&D ecosystem.
It’s launching sometime in 2025, so we’ll see how hard they push it when it’s ready. So far, they’ve only hinted at it. I don’t know if they’d want to do this, but they could also try to convince other smaller (but still big) streamers to use it too. There are some streamers they’re pretty close with (the Dropout guys for example) and others who they’re on friendly terms with (like Penny Arcade’s guys).
If WotC / Hasbro wanted to mount a charm offensive to get people to keep using D&D, I don’t know how influential they are. Other than Chris Perkins, I can’t think of any well known D&D employees at all.